Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers.

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the presence of clones of mutated blood cells without overt blood diseases. In the last few years, it has emerged that CHIP is associated with atherosclerosis and coronary calcification and that it is an independent determinant of cardiovascular mortality. Recently, CHIP has been found to occur frequently in patients with calcific aortic valve disease (CAVD) and it is associated with a poor prognosis after valve replacement. We assessed the frequency of CHIP by DNA sequencing in the blood cells of 168 CAVD patients undergoing surgical aortic valve replacement or transcatheter aortic valve implantation and investigated the effect of CHIP on 12 months survival. To investigate the pathological process of CAVD in CHIP c

SUBMITTER: Vieceli Dalla Sega F 

PROVIDER: S-EPMC9701688 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature