Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres.

ABSTRACT: Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified potent, small-molecule telomerase inhibitors using a telomerase repeat amplification protocol assay. The results of the assay are the first evidence of telomerase inhibition by anthraquinone derivatives that do not exhibit G-quadruplex-stabilizing properties. The stability of telomerase in the presence of its inhibitor was evaluated under nearly physiological co

SUBMITTER: Maciejewska N 

PROVIDER: S-EPMC9701690 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature