Ontology highlight
ABSTRACT:
SUBMITTER: Yu C
PROVIDER: S-EPMC9701702 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Frontiers in microbiology 20221114
3-Decalinoyltetramic acids (DTAs) are a class of natural products with chemical diversity and potent bioactivities. In fungal species there is a general biosynthetic route to synthesize this type of compounds, which usually features a polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) and a lipocalin-like Diels-Alderase (LLDAse). Using a synthetic biology approach, combining the bioinformatics analysis prediction and heterologous expression, we mined a PKS-NRPS and LLDAse encoding ge ...[more]