Sigma70Pred: A highly accurate method for predicting sigma70 promoter in Escherichia coli K-12 strains.

ABSTRACT: Sigma70 factor plays a crucial role in prokaryotes and regulates the transcription of most of the housekeeping genes. One of the major challenges is to predict the sigma70 promoter or sigma70 factor binding site with high precision. In this study, we trained and evaluate our models on a dataset consists of 741 sigma70 promoters and 1,400 non-promoters. We have generated a wide range of features around 8,000, which includes Dinucleotide Auto-Correlation, Dinucleotide Cross-Correlation, Dinucleotide Auto Cross-Correlation, Moran Auto-Correlation, Normalized Moreau-Broto Auto-Correlation, Parallel Correlation Pseudo Tri-Nucleotide Composition, etc. Our SVM based model achieved maximum accuracy 97.38% with AUROC 0.99 on training dataset, using 200 most relevant features. In order to check the

SUBMITTER: Patiyal S 

PROVIDER: S-EPMC9701712 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature