Early CD4⁺ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory.

ABSTRACT: Longitudinal studies have revealed large interindividual differences in antibody responses induced by SARS-CoV-2 mRNA vaccines. Thus, we performed a comprehensive analysis of adaptive immune responses induced by three doses of the BNT162b2 SARS-CoV-2 mRNA vaccines. The responses of spike-specific CD4⁺ T cells, CD8⁺ T cells and serum IgG, and the serum neutralization capacities induced by the two vaccines declined 6 months later. The 3^rd dose increased serum spike IgG and neutralizing capacities against the wild-type and Omicron spikes to higher levels than the 2^nd dose, and this was supported by memory B cell responses, which gradually increased after the 2^nd dose and were further enhanced by the 3^rd dose. The 3^rd

SUBMITTER: Bai J 

PROVIDER: S-EPMC9701808 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature