GRAP2 is a prognostic biomarker and correlated with immune infiltration in lung adenocarcinoma.

ABSTRACT:

Background

GRAP2 is an adaptor protein involved in leukocyte signal activation; however, the prognostic value of GRAP2 and its correlation with immune infiltration in lung adenocarcinoma (LUAD) are unclear.

Methods

Original data were downloaded from the TCGA database and Gene Expression Omnibus (GEO) database. GRAP2 expression was analyzed with the TCGA and TIMER databases. We evaluated the influence of GRAP2 on clinical prognosis using the Kaplan-Meier plotter, GEO, and GEPIA database. The TIMER and TISIDB databases were used to investigate correlations between GRAP2 expression and cancer immune characteristics. Finally, we confirmed the expression of GRAP2 in LUAD by immunohistochemistry staining.

Results

The transcription levels of GRAP2 were significantly lower in

SUBMITTER: Song S 

PROVIDER: S-EPMC9701895 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature