Serotonin modifies the impact of sleep disturbance on suicidality in patients with acute coronary syndrome

ABSTRACT:

Background

This study investigated the associations of sleep disturbance and serum serotonin levels with suicidal ideation, and evaluated the potential modifying effects of serotonin on these associations in patients with the acute coronary syndrome (ACS).

Methods

In total, 969 ACS patients were recruited from a tertiary university hospital in Korea within 2 weeks of disease onset and evaluated in terms of sleep disturbance (using the Leeds Sleep Evaluation Questionnaire), serum serotonin levels, and suicidal ideation (using the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of suicidal ideation.

SUBMITTER: Kim J 

PROVIDER: S-EPMC9702559 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature