Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment.

ABSTRACT: Tumour development and progression is dependent upon tumour cell interaction with the tissue stroma. Bioengineering the tumour-stroma microenvironment (TME) into 3D biomimetic models is crucial to gain insight into tumour cell development and progression pathways and identify therapeutic targets. Ameloblastoma is a benign but locally aggressive epithelial odontogenic neoplasm that mainly occurs in the jawbone and can cause significant morbidity and sometimes death. The molecular mechanisms for ameloblastoma progression are poorly understood. A spatial model recapitulating the tumour and stroma was engineered to show that without a relevant stromal population, tumour invasion is quantitatively decreased. Where a relevant stroma was engineered in dense collagen populated by gingival fibrobla

SUBMITTER: Bakkalci D 

PROVIDER: S-EPMC9703037 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature