Sex and N-terminal pro B-type natriuretic peptide: The potential mediating role of iron biomarkers.

ABSTRACT:

Background

Levels of N-terminal pro B-type natriuretic peptide (NT-proBNP), a marker of heart failure and cardiovascular risk, are generally higher in women than men. We explored whether iron biomarkers mediate sex differences in NT-proBNP levels.

Methods

We included 5,343 community-dwelling individuals from the Prevention of Renal and Vascular Endstage Disease study. With linear regression analyses, we investigated the association of sex and iron biomarkers with NT-proBNP levels, independent of adjustment for potential confounders. The assessed iron biomarkers included ferritin, transferrin saturation (TSAT), hepcidin, and soluble transferrin receptor (sTfR). Next, we performed mediation analyses to investigate to which extent iron biomarkers influence the association betwe

SUBMITTER: Khatami F 

PROVIDER: S-EPMC9703058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature