Extracellular vesicles of Candida albicans regulate its own growth through the L-arginine/nitric oxide pathway.

ABSTRACT: Candida albicans is the main conditional pathogenic fungus among the human microbiome. Extracellular vesicles (EVs) secreted by C. albicans are important for its pathogenesis. However, the effects and mechanisms of EVs on C. albicans own growth are not clear. Here, we isolated EVs from C. albicans cells grown in four culture media, including RPMI 1640, DMEM, YPD, and YNB, and measured their effects on the own growth of C. albicans in these media. All the C. albicans EVs from the four media could promote the growth of C. albicans in RPMI 1640 and DMEM media, but had no effects in YPD and YNB media, indicating that the effects of EVs on C. albicans growth were dependent on some media contents. By comparing the media contents and transcriptome analysis, arginine was identified as the key fact

SUBMITTER: Wei Y 

PROVIDER: S-EPMC9703431 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature