TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging.

ABSTRACT: TLR9 is a critical nucleic acid sensing receptor in mediating periodontitis and periodontitis-associated comorbidities. Emerging evidence implicates TLR9 as a key sensor during aging, although its participation in periodontal aging is unexplored. Here, we investigated whether TLR9-mediated host responses can promote key hallmarks of aging, inflammaging, and senescence, in the course of periodontitis using a multipronged approach comprising clinical and preclinical studies. In a case-control model, we found increased TLR9 gene expression in gingival tissues of older (≥55 y) subjects with periodontitis compared to older healthy subjects as well as those who are younger (<55 y old) with and without the disease. Mechanistically, this finding was supported by an in vivo model in which wild-type

SUBMITTER: Albuquerque-Souza E 

PROVIDER: S-EPMC9703528 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature