Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.

ABSTRACT: Gasdermins, a family of five pore-forming proteins (GSDMA-GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), which recruits immune cells to infection sites and promotes protective immunity^1,2. Pore formation is triggered by gasdermin cleavage^1,2. Although the proteases that activate GSDMB, C, D and E have been identified, how GSDMA-the dominant gasdermin in the skin-is activated, remains unknown. Streptococcus pyogenes, also known as group A Streptococcus (GAS), is a major skin pathogen that causes substantial morbidity and mortality worldwide³. Here we show that the GAS cysteine protease SpeB virulence factor triggers keratinocyte pyroptosis by cleaving GSDMA

SUBMITTER: Deng W 

PROVIDER: S-EPMC9703647 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature