Inhibitory effect of anti-Scg3 on corneal neovascularization: a preliminary study.

ABSTRACT:

Background

Corneal neovascularization (CNV) is an important disease that causes blindness. Secretogranin III (Scg3) has emerged as a new influencing factor of neovascularization. This study analyzed the Scg3 antibody's inhibitory effect on CNV and and explored its preliminary mechanism.

Methods

Human umbilical vein endothelial cells (HUVECs) were treated with Scg3 and anti-Scg3. Cell proliferation, wound healing migration and tube formation assays were performed. Healthy adult New Zealand rabbits were randomly selected to be alkali burned and establish the corneal neovascularization (CNV) model. The rabbits were randomly divided into 3 groups (the high concentration group, low concentration group and control group). Different doses of anti-Scg3 and PBS were administered to t

SUBMITTER: Jin H 

PROVIDER: S-EPMC9703748 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature