NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is mainly characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition dysfunction has received extensive attention from scholars. Astrocytes are essential in neurocognitive deficits via A1/A2 phenotypic changes. Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is considered the most important factor inducing and maintaining neuroinflammation. However, whether the NLRP3 regulates the A1/A2 transformation of astrocytes in CIH-related brain injury remains unclear.

Methods

We constructed an OSA-related CIH animal model and assessed the rats' learning ability in the Morris water maze; the histopat

SUBMITTER: She N 

PROVIDER: S-EPMC9703760 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature