Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation.

ABSTRACT:

Background

The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We previously revealed that the remodeling of mesenchyme with collagen fibril induces YAP/TAZ-dependent fate conversion of intestinal/colonic epithelial cells covering the wound bed towards fetal-like progenitors. To fully elucidate the mechanisms underlying the link between extracellular matrix (ECM) remodeling of mesenchyme and fetal-like reprogramming of epithelial cells, it is critical to understand how collagen type I influence the phenotype of epithelial cells. In this study, we utilize collagen sphere, which is the epithelial organoids cultured in purified collage

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC9703763 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature