In vitro and in vivo production and split-intein mediated ligation (SIML) of circular bacteriocins

ABSTRACT: Circular bacteriocins are antimicrobial peptides produced by bacteria that after synthesis undergo a head-to-tail circularization. Compared to their linear counterparts, circular bacteriocins are, in general, very stable to temperature and pH changes and more resistant to proteolytic enzymes, being considered as one of the most promising groups of antimicrobial peptides for their potential biotechnological applications. Up to now, only a reduced number of circular bacteriocins have been identified and fully characterized, although many operons potentially coding for new circular bacteriocins have been recently found in the genomes of different bacterial species. The production of these peptides is very complex and depends on the expression of different genes involved in their synthesis, ci

SUBMITTER: Pena N 

PROVIDER: S-EPMC9703936 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature