Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection.

ABSTRACT:

Background

Numerous studies have noted the effect of chorda tympani (CT) nerve transection on taste sensitivity yet very few have directly observed its effects on taste receptor and taste signaling protein expressions in the tongue tissue.

Methods

In this study, bilateral CT nerve transection was performed in adult Sprague Dawley rats after establishing behavioral taste preference for sweet, bitter, and salty taste via short term two-bottle preference testing using a lickometer setup. Taste preference for all animals were subsequently monitored. The behavioral testing was paired with tissue sampling and protein expression analysis. Paired groups of CT nerve transected animals (CTX) and sham operated animals (SHAM) were sacrificed 7, 14, and 28 days post operation.

SUBMITTER: Padalhin A 

PROVIDER: S-EPMC9703994 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature