Tau-PET and multimodal imaging in clinically atypical multiple system atrophy masquerading as progressive supranuclear palsy.

ABSTRACT:

Introduction

Multiple system atrophy (MSA) typically presents with parkinsonism, ataxia and/or autonomic dysfunction. Occasionally, clinically atypical (ca-MSA) cases masquerade as progressive supranuclear palsy (PSP). We aimed to investigate whether different neuroimaging modalities could facilitate differentiation and whether histopathologic characteristics could explain the atypical presentation.

Methods

We identified 3 neuropathologically-defined ca-MSA patients with clinically diagnosed PSP who underwent various antemortem brain imaging: MRI and PET imaging using ¹¹C-Pittsburgh compound B, ¹⁸F-flortaucipir, and ¹⁸F-fluorodeoxyglucose. We compared clinical features, brainstem planimetry, and radiotracer standardized uptake value ratios in

SUBMITTER: Carlos AF 

PROVIDER: S-EPMC9704374 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature