Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.

ABSTRACT:

Introduction

Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).

Aim

To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.

Material and methods

The study group consisted of 191 patients with AD and 168 controls.

Results

The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, p = 0.01).

Conclusions

The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.

SUBMITTER: Zaryczanska A 

PROVIDER: S-EPMC9704459 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature