Mechanism of gene network in the treatment of intracerebral hemorrhage by natural plant drugs in Lutong granules.

ABSTRACT:

Purpose

To study the effects of Lu-tong Granules (LTG) in ICH etermine the underlying mechanism of molecular network.

Methods

Modern bioinformatics and network pharmacology methods were used to predict molecular network mechanisms between ICH and LTG. Animal experiments were carried out to verify the effect of LTG for the treatment of ICH, combined with behavior test and morphologic detection.

Results

Forty-three active components in LTG and involved 192 gene targets were identified successfully. Moreoner, they were intersected with 1132 genes of ICH,88 intersection targets were obtained. subsequently, Cytoscape was used to screen Hub genes, in which,6 core molecules, including AKT1, IL6, VEGFA, CASP3, JUN and MMP9 were recognized. Furthermore, we constructed Six core

SUBMITTER: Sun J 

PROVIDER: S-EPMC9704616 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature