Conversion of CO₂ into organic acids by engineered autotrophic yeast.

ABSTRACT: The increase of CO₂ emissions due to human activity is one of the preeminent reasons for the present climate crisis. In addition, considering the increasing demand for renewable resources, the upcycling of CO₂ as a feedstock gains an extensive importance to establish CO₂-neutral or CO₂-negative industrial processes independent of agricultural resources. Here we assess whether synthetic autotrophic Komagataella phaffii (Pichia pastoris) can be used as a platform for value-added chemicals using CO₂ as a feedstock by integrating the heterologous genes for lactic and itaconic acid synthesis. ¹³C labeling experiments proved that the resulting strains are able to produce organic acids via the assimilation of CO₂

SUBMITTER: Baumschabl M 

PROVIDER: S-EPMC9704707 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature