Somatic 9p24.1 alterations in HPV^- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity.

ABSTRACT: Somatic copy number alterations (SCNAs), generally (1) losses containing interferons and interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune checkpoint therapy (ICT)-resistant tumors (2); however, genomic regions mediating these effects are unclear and probably tissue specific. Previously, 9p21.3 loss was found to be an early genetic driver of human papillomavirus-negative (HPV^-) head and neck squamous cancer (HNSC), associated with an immune-cold tumor microenvironment (TME) signal, and recent evidence suggested that this TME-cold phenotype was greatly enhanced with 9p21 deletion size, notably encompassing band 9p24.1 (3). Here, we report multi-omic, -threshold and continuous-variable dissection of 9p21 and 9p24 loci (including depth and degree of somat

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9704728 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature