Antibiotic tolerance and persistence have distinct fitness trade-offs.

ABSTRACT: Genetically susceptible bacteria can escape the action of bactericidal antibiotics through antibiotic tolerance or persistence. However, one major difference between the two phenomena is their distinct penetrance within an isogenic population. While with antibiotic persistence, susceptible and persister cells co-exist, antibiotic tolerance affects the entire bacterial population. Here, we show that antibiotic tolerance can be achieved in numerous non-specific ways in vitro and during infection. More importantly, we highlight that, due to their impact on the entire bacterial population, these tolerance-inducing conditions completely mask persistence and the action of its molecular determinants. Finally, we show that even though tolerant populations display a high survival rate under bacteri

SUBMITTER: Michaux C 

PROVIDER: S-EPMC9704765 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature