Transcriptional substrates underlying functional connectivity profiles of subregions within the human sensorimotor cortex.

ABSTRACT: The human sensorimotor cortex has multiple subregions showing functional commonalities and differences, likely attributable to their connectivity profiles. However, the molecular substrates underlying such connectivity profiles are unclear. Here, transcriptome-neuroimaging spatial correlation analyses were performed between transcriptomic data from the Allen human brain atlas and resting-state functional connectivity (rsFC) of 24 fine-grained sensorimotor subregions from 793 healthy subjects. Results showed that rsFC of six sensorimotor subregions were associated with expression measures of six gene sets that were specifically expressed in brain tissue. These sensorimotor subregions could be classified into the polygenic- and oligogenic-modulated subregions, whose rsFC were related to gene

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9704778 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature