Pan-Cancer Analysis of TLE3 Revealed Its Value in Tumor Microenvironment and Prognosis.

ABSTRACT:

Background

Transducin-like enhancer of split 3 (TLE3), a member of the TLE gene family, is related to tumor genesis and progression. However, whether TLE3 played a crucial role in the whole pan-cancer remained unknown.

Methods

Comprehensive analysis of TCGA, GEO, and GTEx data with an online tool, and R language was performed to explore the relationship of TLE3 expression between prognosis, gene mutation, protein phosphorylation, DNA methylation, tumor microenvironment, and related pathways in 33 tumors.

Results

TLE3 was high-expressed in most tumors, and TLE3 expression and the prognosis of some tumor types were significantly correlated. The level of TLE3 expression in 33 cancer types was closely associated with DNA methylation. High-level phosphorylation site

SUBMITTER: Li T 

PROVIDER: S-EPMC9705091 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature