Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling.
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ABSTRACT:
SUBMITTER: Normile TG
PROVIDER: S-EPMC9705245 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling.
Normile Tyler G TG Chu Timothy H TH Sheridan Brian S BS Del Poeta Maurizio M
Mucosal immunology 20220601 6
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects mice from a subsequent infection even during CD4<sup>+</sup> T cells deficiency, a condition commonly associated with cryptococcosis. Here, we studied the immune mechanism that confers host protection during CD4<sup>+</sup>T deficiency. Mice receiving Δsgl1 vaccine produce IFNγ and IL-17A during CD4<sup>+</sup> T (or CD8<sup>+</ ...[more]
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