Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis.

ABSTRACT: Breast cancer, the most frequent cancer in women, is generally classified into several distinct histological and molecular subtypes. However, single-cell technologies have revealed remarkable cellular and functional heterogeneity across subtypes and even within individual breast tumors. Much of this heterogeneity is attributable to dynamic alterations in the epigenetic landscape of the cancer cells, which promote phenotypic plasticity. Such plasticity, including transition from luminal to basal-like cell identity, can promote disease aggressiveness. We now report that the tumor suppressor LATS1, whose expression is often downregulated in human breast cancer, helps maintain luminal breast cancer cell identity by reducing the chromatin accessibility of genes that are characteristic of a "bas

SUBMITTER: Aylon Y 

PROVIDER: S-EPMC9705295 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature