The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice.

ABSTRACT: Ceruloplasmin (CP) plays an important role in maintaining iron homeostasis. Cp gene knockout (Cp^-/-) mice develop a neurodegenerative disease with aging and show iron accumulation in the brain. However, iron deficiency has also been observed in 3 M Cp^-/- mice. The use of systemic Cp gene knockout is insufficient to reveal specific functions for CP in the central nervous system. Considering recent discoveries that astrocytes synthetize the majority of brain CP, we generated astrocyte conditional Cp knockout (Cp^GfapcKO) mice, and found that iron contents decreased in the cerebral cortex and hippocampus of young (6 M) and old (18 M) Cp^GfapcKO mice. Further experiments revealed that 6 M Cp^GfapcKO mice exhibited impaired learning and memory

SUBMITTER: Li ZD 

PROVIDER: S-EPMC9705310 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature