Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer.

ABSTRACT: Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles in tumor progression and immunosuppression. However, the influence of inflammatory conditions on the tumor response to immune checkpoint inhibitors (ICI) is incompletely understood. Here we show that in a patient with high microsatellite instability (MSI-H) CRC and a local inflammatory condition, the primary tumor progresses but its liver metastasis regresses upon Pembrolizumab treatment. In silico investigation prompted by this observation confirms correlation between inflammatory conditions and poor tumor response to PD-1 blockade in MSI-H CRCs, which is further validated in a cohort of 62 patients retrospectively enrolled to our study. Inhibition of local but not systemic imm

SUBMITTER: Sui Q 

PROVIDER: S-EPMC9705377 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature