Improvement of Outcome for Treatment of 'Restenosis-prone' Vascular Lesions? Potential Impact of the Paclitaxel dose on Late Lumen Loss in Porcine Peripheral Arteries.

ABSTRACT:

Purpose

Clinical data indicate that the drug density on drug-coated balloons (DCBs) might have a role on treatment effect and durability. The aim of the current study was to investigate inhibition of neointimal formation and potential adverse effects after treatment with a novel double-dose DCB in swine.

Material and methods

A four-week study was performed in peripheral arteries of 12 domestic pigs after vessel injury and stent implantation. The novel double-dose DCB with 6-µg paclitaxel (Ptx)/mm² balloon surface (1 × 6) was compared to a standard DCB with 3.5 µg Ptx/mm² (3.5) and uncoated balloons (POBA). Potential adverse effects were stimulated by using three fully overlapping DCBs with 6 µg Ptx/mm² each (3 × 6). Quantitative angiography,

SUBMITTER: Gemeinhardt O 

PROVIDER: S-EPMC9705460 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature