Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study.

ABSTRACT: Various studies have described the roles of myeloid-derived suppressor cells (MDSCs) in pathological conditions, but relatively few have described them under normal physiological conditions. Accumulation of MDSCs is important creating an anti-inflammation environment, which is essential for fertilized egg implantation. This study was designed to record the dynamic changes in MDSC-like cells composition during the menstrual period (MP) and ovulation period (OP) in healthy volunteers over the course of a single menstrual cycle to explore the association between MDSCs and the menstrual cycle under normal physiological conditions. The ratio of MDSC-like cells was higher in MP samples, whereas the activity of Arg-1 was higher during the OP window. There was a negative correlation between the ra

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9705596 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature