Activation of IL1 signaling molecules by Kaposi’s sarcoma-associated herpesvirus

ABSTRACT:

Objective

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s sarcoma (KS) and Primary effusion lymphoma (PEL), which are usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin1 (IL1) family is a major mediator for inflammation response and has functional role in both innate and adaptive immunity. In contrast to the well-studied IL1 molecules, the activation and functional role of IL1 receptor/co-receptor and other related ligands, such as the IL1 receptor accessory protein (IL1RAP), in KSHV pathogenesis and tumorigenesis remain almost unknown.

Methods

In the current study, a series of KSHV negative and positive primary or tumor cells, as well as AIDS-KS tumor sampl

SUBMITTER: Chen J 

PROVIDER: S-EPMC9705745 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature