Characterizing microbiota and metabolomics analysis to identify candidate biomarkers in lung cancer.

ABSTRACT:

Background

Lung cancer is the leading malignant disease and cause of cancer-related death worldwide. Most patients with lung cancer had insignificant early symptoms so that most of them were diagnosed at an advanced stage. In addition to factors such as smoking, pollution, lung microbiome and its metabolites play vital roles in the development of lung cancer. However, the interaction between lung microbiota and carcinogenesis is lack of systematically characterized and controversial. Therefore, the purpose of this study was to excavate the features of the lung microbiota and metabolites in patients and verify potential biomarkers for lung cancer diagnosis.

Methods

Lung tissue flushing solutions and bronchoalveolar lavage fluid samples came from patients with lung cancer and

SUBMITTER: Liu B 

PROVIDER: S-EPMC9705781 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature