Establishment of a reverse genetics system for rabies virus strain Komatsugawa.
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ABSTRACT:
SUBMITTER: Takahashi T
PROVIDER: S-EPMC9705820 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Establishment of a reverse genetics system for rabies virus strain Komatsugawa.
Takahashi Tatsuki T Inukai Maho M Izumi Fumiki F Fujii Yuji Y Nishiyama Shoko S Masatani Tatsunori T Sugiyama Makoto M Ito Naoto N
The Journal of veterinary medical science 20220929 11
The rabies virus strain Komatsugawa isolated from a dog in Tokyo in the 1940s retains biological properties as a field strain, providing an effective model for studying rabies pathogenesis. To facilitate molecular studies on the pathogenesis, this study aimed to establish a reverse genetics system for the Komatsugawa strain. By transfecting the full-length genome plasmid of this strain, infectious virus with artificially introduced genetic markers in its genome was rescued. The recombinant strai ...[more]
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