Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension

ABSTRACT:

Background and aims

Evidence indicates that serum Klotho concentration is associated with mortality in patients with chronic kidney disease (CKD). However, evidence on this association among people with hypertension is scarce. Therefore, we aimed to examine the association between serum Klotho concentration and all-cause and cardiovascular mortality in American patients with hypertension.

Methods and results

We included 6,778 participants with hypertension from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. A Cox proportional hazard model was used to compute the hazard ratios (HRs) and 95% confidence intervals (CIs). The correlation between serum Klotho concentration and mortality was determined using restricted cubic spline and piecewise linear

SUBMITTER:  

PROVIDER: S-EPMC9705974 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature