Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression.

ABSTRACT:

Background

Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and explore candidate genes involving the interactions.

Methods

Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn's disease (CD), and total IBD (CD + UC) respectively. The effects of interactions between gut microbiome and IBD on depression were assessed through a linear regression model. Moreover, for observed significant interactions between gut microbiome

SUBMITTER: Qin X 

PROVIDER: S-EPMC9706134 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature