Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas.

ABSTRACT: Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3) are transcription factors that orchestrate gene regulatory networks required for the balance between keratinocyte differentiation and proliferation. Absence of either protein results in the lack of a normal stratified epidermis with keratinocytes failing to stop proliferating and to terminally differentiate. Numerous pathological variants within IRF6 and GRHL3 have been identified in orofacial cleft-affected individuals and expression of the two transcription factors has been found to be often dysregulated in cancers. However, whether orofacial cleft-associated IRF6 and GRHL3 variants in patients might also affect their cancer risk later in life, is not clear yet. The fact t

SUBMITTER: Parisi L 

PROVIDER: S-EPMC9706198 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature