Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.

ABSTRACT:

Purpose

The aim of this study was to evaluate ceftazidime pharmacokinetics (PK) in a cohort that includes a predominate number of children and adolescents with obesity and assess the efficacy of competing dosing strategies.

Methods

A population PK model was developed using opportunistically collected plasma samples. For each dosing strategy, model-based probability of target attainment (PTA) estimates were computed for study participants using empirical Bayes estimates. In addition, the effects of body size and renal function on PTA were evaluated using stochastic model simulations with virtually generated subjects.

Results

Twenty-nine participants, 24 of whom were obese, contributed data towards the analysis. The median (range) age, body weight, and body mass index o

SUBMITTER: Maharaj AR 

PROVIDER: S-EPMC9706343 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature