Genetic encoding of isobutyryl-, isovaleryl-, and β-hydroxybutryl-lysine in E. coli.

ABSTRACT: Here we report the synthesis and genetic encoding of the lysine post translational modifications, β-hydroxybutyryl-lysine, isobutyryl-lysine and isovaleryl-lysine. The ability to obtain a homogenous protein samples with site-specific incorporation of these acylated lysine residues can serve as a powerful tool to study the biological role of lysine post translational modifications.

SUBMITTER: Christopher JA 

PROVIDER: S-EPMC9706372 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature