Adoptive therapy with amyloid-β specific regulatory T cells alleviates Alzheimer's disease.

ABSTRACT: Rationale: Neuroinflammation is a primary feature of Alzheimer's disease (AD), for which an increasing number of drugs have been specifically developed. The present study aimed to define the therapeutic impact of a specific subpopulation of T cells that can suppress excessive inflammation in various immune and inflammatory disorders, namely, CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs). Methods: To generate Aβ antigen-specific Tregs (Aβ⁺ Tregs), Aβ 1-42 peptide was applied in vivo and subsequent in vitro splenocyte culture. After isolating Tregs by magnetic bead based purification method, Aβ⁺ Tregs were adoptively transferred into 3xTg-AD mice via tail vein injection. Therapeutic efficacy was confirmed with be

SUBMITTER: Yang H 

PROVIDER: S-EPMC9706584 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature