Current use and future potential of (physiologically based) pharmacokinetic modelling of radiopharmaceuticals: a review.

ABSTRACT: Rationale: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PK) modelling approaches are widely accepted in non-radiopharmaceutical drug development and research, while there is no major role for these approaches in radiopharmaceutical development yet. In this review, a literature search was performed to specify different research purposes and questions that have previously been answered using both PBPK and population PK modelling for radiopharmaceuticals. Methods: The literature search was performed using the databases PubMed and Embase. Wide search terms included radiopharmaceutical, tracer, radioactivity, physiologically based pharmacokinetic model, PBPK, population pharmacokinetic model and nonlinear mixed-effects model. Results: Eight a

SUBMITTER: Siebinga H 

PROVIDER: S-EPMC9706588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature