Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfβ-Dependent Mechanisms.

ABSTRACT:

Significance

Most patients with bladder cancer do not respond to ICB targeting of the PD-L1 signaling axis. Our modeling applied a de novo resistance signature to show that tumor-infiltrating myeloid cells promote poor treatment response in a TGFβ-dependent mechanism.

SUBMITTER: Yu H 

PROVIDER: S-EPMC9706595 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature