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Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfβ-Dependent Mechanisms.

ABSTRACT:

Significance

Most patients with bladder cancer do not respond to ICB targeting of the PD-L1 signaling axis. Our modeling applied a de novo resistance signature to show that tumor-infiltrating myeloid cells promote poor treatment response in a TGFβ-dependent mechanism.

SUBMITTER: Yu H

PROVIDER: S-EPMC9706595 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfβ-Dependent Mechanisms.

Yu Haocheng H Sfakianos John P JP Wang Li L Hu Yang Y Daza Jorge J Galsky Matthew D MD Sandhu Harkirat S HS Elemento Olivier O Faltas Bishoy M BM Farkas Adam M AM Bhardwaj Nina N Zhu Jun J Mulholland David J DJ

Molecular cancer therapeutics 20221101 11

<h4>Significance</h4>Most patients with bladder cancer do not respond to ICB targeting of the PD-L1 signaling axis. Our modeling applied a de novo resistance signature to show that tumor-infiltrating myeloid cells promote poor treatment response in a TGFβ-dependent mechanism. ...[more]

PMID: 36129800

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Tumor-Infiltrating Myeloid Cells Confer de novo Resistance to PD-L1 Blockade through EMT-stromal and Tgf-beta Dependent Mechanisms

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Tumor-Infiltrating Myeloid Cells Confer de novo Resistance to PD-L1 Blockade through EMT-stromal and Tgf-beta Dependent Mechanisms

Project description:Tumor-Infiltrating Myeloid Cells Confer de novo Resistance to PD-L1 Blockade through EMT-stromal and Tgf-beta Dependent Mechanisms

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