Fibroblast growth factor 23 inhibits osteogenic differentiation and mineralization of chicken bone marrow mesenchymal stem cells.

ABSTRACT: Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is involved in the reabsorption of phosphate (P) and the production of vitamin D hormones in the kidney. However, whether and how FGF23 regulates chicken bone metabolism remains largely unknown. In the present study, we investigated the effect of FGF23 on osteogenic differentiation and mineralization of chicken bone marrow mesenchymal stem cells (BMSCs). First, we found that the transcription of FGF23 was inhibited by β-glycerophosphate sodium (GPS, 5 mM, 10 mM, 20 mM) and 10^-9 M 1, 25-dihydroxyvitamin D3 (1, 25(OH)₂D₃), but was stimulated by 10^-7 M 1, 25(OH)₂D₃ and parathyroid hormone (PTH, 10^-9 M, 10^-8 M, 10^-7 M). Second, overexpr

SUBMITTER: Lyu Z 

PROVIDER: S-EPMC9706642 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature