Associations between PM_2.5 exposure and Alzheimer's Disease prevalence Among elderly in eastern China.

ABSTRACT:

Background

Studies showed that PM_2.5 might be associated with various neurogenic diseases such as Alzheimer's Disease (AD). However, this topic had been little studied in Zhejiang province of China.  METHODS: In 2018, we established a cohort of AD high-risk population with 1,742 elderly aged 60 and above. In 2020, the cohort was followed up, a total of 1,545 people participated the 2 surveys. Data collection included questionnaires and basic physical examinations. The average residential exposure to PM_2.5 for each participant, that in a 5-years period prior to the first survey, was estimated using a satellite-based spatial statistical model. We determined the association between PM_2.5 and AD prevalence by cox proportional hazards regression model. 

SUBMITTER: Yang L 

PROVIDER: S-EPMC9706836 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature