Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma.

ABSTRACT:

Background

Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation. This study aimed to measure and compare peripheral levels of complement C3, C3a, C1q and C-reactive protein (CRP) in MDD patients and healthy controls and explore the relationship between these molecule levels and childhood trauma history in the participants.

Methods

The participants were 49 medication-free MDD patients and 45 healthy controls. All participants were asked to finish the Childhood Trauma Questionnaire, followed by blood sampling for measurement of plasma complement C3, C3a, C1q and CRP by means of enzyme-linked immunosorbent

SUBMITTER: Luo X 

PROVIDER: S-EPMC9706857 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature