Timing of dialysis in acute kidney injury using routinely collected data and dynamic treatment regimes.

ABSTRACT:

Background and objectives

Defining the optimal moment to start renal replacement therapy (RRT) in acute kidney injury (AKI) remains challenging. Multiple randomized controlled trials (RCTs) addressed this question whilst using absolute criteria such as pH or serum potassium. However, there is a need for identification of the most optimal cut-offs of these criteria. We conducted a causal analysis on routinely collected data (RCD) to compare the impact of different pre-specified dynamic treatment regimes (DTRs) for RRT initiation based on time-updated levels of potassium, pH, and urinary output on 30-day ICU mortality.

Design, setting, participants, and measurements

Patients in the ICU of Ghent University Hospital were included at the time they met KDIGO-AKI-stage ≥ 2. We appl

SUBMITTER: Morzywolek P 

PROVIDER: S-EPMC9706864 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature