Comprehensive analysis of ID genes reveals the clinical and prognostic value of ID3 expression in acute myeloid leukemia using bioinformatics identification and experimental validation.

ABSTRACT:

Background

Dysregulation of inhibitor of differentiation/DNA binding (ID) genes is linked to cancer growth, angiogenesis, invasiveness, metastasis and patient survival. Nevertheless, few investigations have systematically determined the expression and prognostic value of ID genes in acute myeloid leukemia (AML).

Methods

The expression and clinical prognostic value of ID genes in AML were first identified by public databases and further validated by our research cohort.

Results

Using public data, the expression of ID1/ID3 was markedly downregulated in AML, and the expression of ID2 was greatly upregulated in AML, whereas ID4 showed no significant difference. Among the ID genes, only ID3 expression may be the most valuable prognostic biomarker in both total AML and cyto

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC9707109 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature