IGF2BP3 is an essential N⁶-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells.

ABSTRACT: A lack of promising targets leads to poor prognosis in patients with lung adenocarcinoma (LUAD). Therefore, it is urgent to identify novel therapeutic targets. The importance of the N⁶-methyladenosine (m⁶A) RNA modification has been demonstrated in various types of tumors; however, knowledge of m⁶A-related proteins in LUAD is still limited. Here, we found that insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), an m⁶A reader protein, is highly expressed in LUAD and associated with poor prognosis. IGF2BP3 desensitizes ferroptosis (a new form of regulated cell death) in a manner dependent on its m⁶A reading domain and binding capacity to m⁶A-methylated mRNAs encoding anti-ferroptotic factors, including but not limit

SUBMITTER: Xu X 

PROVIDER: S-EPMC9707255 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature