Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis.

ABSTRACT:

Objectives

To identify groups of people with RA with different disability trajectories over 10 years, despite comparable levels of inflammation.

Methods

Data for this analysis came from three European prospective cohort studies of people with RA [Norfolk Arthritis Register (NOAR), Early RA Network (ERAN), Étude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR)]. Participants were assessed regularly over 8 (ERAN) to 10 (NOAR/ESPOIR) years. Inclusion criteria were: recruited after 1 January 2000, <24 months baseline symptom duration, and disability (HAQ) and inflammation [two-component DAS28 (DAS28-2C)] recorded at baseline and at one other follow-up. People in each cohort also completed patient-reported outcome measures at each assessment (pain, fatigue, depressive

SUBMITTER: Gwinnutt JM 

PROVIDER: S-EPMC9707289 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature