The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder.

ABSTRACT:

Background

Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear.

Aims

To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder.

Method

Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified

SUBMITTER: Chen WY 

PROVIDER: S-EPMC9707506 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature